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IJE OxfordTraa, B.S., et al., Antibiotics for the treatment of dysentery in children. Int J Epidemiol, 2010. 39 Suppl 1: p. i70-4.

Abstract

Background Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years.

Methods We reviewed all literature reporting the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. We used a standardized abstraction and grading format and performed meta-analyses to determine the effect of treatment with these antibiotics on rates of treatment failure, bacteriological failure and bacteriological relapse. The CHERG Standard Rules were applied to determine the final effect of treatment with these antibiotics on diarrhoea mortality.

Results Eight papers were selected for abstraction. Treatment with ciprofloxacin, ceftriaxone or pivmecillinam resulted in a cure rate of >99% while assessing clinical failure, bacteriological failure and bacteriological relapse.

Conclusions The antibiotics recommended by the WHO—ciprofloxacin, ceftriaxone and pivmecillinam—are effective in reducing the clinical and bacteriological signs and symptoms of dysentery and thus can be expected to decrease diarrhoea mortality attributable to dysentery.

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LiST Team Holds Three Workshops for Nutrition-Focused Users

November 17, 2016 – Under a project supported by the Children’s Investment Fund Foundation (CIFF), the LiST team has conducted an extensive update of all aspects of the LiST model linked to nutrition interventions and outcomes. The objectives of this project were to make the LiST software more useful for researchers, program planners, and policy makers in the nutrition sector.

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